IT has been widely suggested that sperm quality plays a role in pregnancy outcomes, including miscarriage. While traditionally, miscarriages have been attributed to factors affecting the mother, sperm DNA damage and abnormal morphology are being recognised as contributing factors in some cases. Since the mother is the one whose body carries a pregnancy, it is not surprising that many suspected causes of miscarriage have to do with factors present in the mother. The father’s role, or more specifically his sperm, has often been overlooked in the past.
However, there may be cases where sperm quality can affect a pregnancy and even be responsible for a miscarriage. Hence, it’s important to keep in mind that quite often there is no obvious explanation for a miscarriage. Fewer than half of all miscarriages seen have an identifiable cause. This can be frustrating, especially if you have experienced multiple miscarriages. About two-thirds of women who experience recurring pregnancy loss go on to have a healthy pregnancy. In the past, most of the attention has focused on women.
Fertility experts agree that more research is needed, but more is known today than ever before. From abnormal chromosomes to sperm DNA fragmentation, even lifestyle choices, there are many ways that sperm can affect the outcome of a pregnancy. It is recommended that when miscarriages occur, especially multiple times, testing focuses on the father as well as the mother. The leading causes of miscarriage are chromosome problems. Chromosomes are blocks of DNA that encode all the information needed during development. Because half of a developing baby’s chromosomes come from the father, it is possible that he may contribute abnormal chromosomes to a pregnancy.
About three out of four miscarriages occur during the first trimester of pregnancy. Typically, if a woman has a miscarriage during the first trimester, it is very likely to do with the baby’s chromosomes. With chromosomal problems, something goes awry during conception and an embryo gets the wrong number of chromosomes (too many or too few). This may eventually result in miscarriage. Not all babies with the wrong number of chromosomes are miscarried, though. For example, babies with trisomy 21 have Down’s syndrome.
In the past, researchers have focused on the egg as the main source of chromosome problems. One reason is that (usually) only one egg is ovulated each menstrual cycle. With sperm, natural selection takes place before fertilization that theoretically should lead to the “fittest” being the ones to reach the egg.
Additionally, genetic studies on tissue from miscarriages have traced errors in the first stage of maternal meiosis (early development of the egg) as being the most likely source of the abnormalities that cause miscarriages. But some research over the past decade suggests that this might not always be the case. Some cases of recurrent miscarriages seem to involve the father having a high incidence of abnormal chromosomes in his sperm. There aren’t any real estimates for how frequently the sperm is a factor in recurrent miscarriages, and chromosome problems in sperm aren’t believed to be a major cause of repeat losses. It does seem to be a possibility—especially in men whose sperm showed abnormal morphology or other markers of low fertility.
One of the keys to sperm quality lies in the DNA, which can become damaged. When this damage occurs, it is called sperm DNA fragmentation (SDF) and this is an area of focus for many research studies that are looking into the causes of miscarriage. Sperm DNA Fragmentation can occur for any number of reasons. Among these are cell death, environmental toxins, and illness or fever. Sperm cannot repair cell damage like other cells in the body and this is a leading cause of male infertility. The damage also affects the DNA structure within the sperm and if it fertilizes an egg, this can potentially.
